The effects of radon exposure on cognitive health and mitochondrial function
Official title: Radon exposure in relation to the risk of cognitive impairment and mitochondrial function
Funded at Columbia University Health Sciences · NIH-10591204 · Data updated 2026-11-12
This study is looking at how being around radon gas, which you can't see or smell, might affect brain health and memory, especially in places where radon levels are high, to help find ways to prevent or treat cognitive decline related to Alzheimer's and similar conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,396,221 |
| NIH project number | 1RF1AG077255-01A1 |
| Project ID | NIH-10591204 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living in areas with high radon exposure who are concerned about cognitive health or have a family history of neurological disorders.
✕Less likely to help
Patients who do not live in radon-affected areas or those without concerns about cognitive impairment may not benefit from this research.
What this research studies
This research investigates how exposure to radon gas, a colorless and odorless radioactive substance, may influence cognitive impairment and mitochondrial function. The study aims to understand the geographic variations in Alzheimer's disease and related dementias, particularly in areas with high radon levels. By examining the biological mechanisms through which radon exposure affects the brain, including oxidative stress and DNA damage, the research seeks to uncover potential links between environmental factors and neurological health. Patients may benefit from insights that could lead to preventive measures or treatments for cognitive decline associated with radon exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for cognitive impairment linked to environmental toxins like radon.
How similar studies have gone: Previous research has established a connection between radon exposure and lung cancer, but the specific impact on cognitive function is still being explored, making this a novel investigation.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Kahe, Ka — Columbia University Health Sciences
- Study coordinator: Kahe, Ka
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.