The effects of prescription opioids on brain structure and thinking in older adults with chronic pain
Prescription opioids, brain structure, and cognition in older adults with chronic pain
This study is looking at how prescription painkillers, like opioids, might change the brain and affect thinking skills in older adults with chronic pain, so we can better understand how these medications impact their minds compared to the pain itself.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11023761 on NIH RePORTER |
What this research studies
This research investigates how prescription opioids affect brain structure and cognitive function in older adults suffering from chronic pain. It aims to differentiate the cognitive impacts of opioids from those caused by the pain itself, addressing critical gaps in understanding this relationship. The study will utilize advanced imaging techniques to assess brain changes and cognitive assessments to evaluate thinking skills over time. By exploring these connections, the research seeks to uncover the biological mechanisms behind opioid use and cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are experiencing chronic pain and are currently prescribed opioids.
Not a fit: Patients who are younger than 65 or those not using prescription opioids for chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for managing chronic pain in older adults, potentially reducing cognitive decline associated with opioid use.
How similar studies have performed: Previous studies have indicated a link between opioid use and cognitive decline, but this research aims to provide novel insights into the underlying mechanisms and causative factors.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Warner, Nafisseh S — Mayo Clinic Rochester
- Study coordinator: Warner, Nafisseh S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.