The effects of past tuberculosis on long-term health and immune response
Official title: Post-TB epigenetic scars' impact on long-term inflammation, immunity and mortality
Funded at Baylor College of Medicine · NIH-10878006 · Data updated 2026-11-12
This study is looking at how surviving tuberculosis can lead to long-term health problems by checking for changes in your DNA that might affect your immune system, and it’s for people who have recovered from TB to help understand why some may face higher health risks later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $733,050 |
| NIH project number | 5R01AI170774-02 |
| Project ID | NIH-10878006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently completed treatment for tuberculosis.
✕Less likely to help
Patients who have not been treated for tuberculosis or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates how tuberculosis (TB) survivors experience long-term health issues due to lasting changes in their DNA that affect inflammation and immune responses. The study will follow TB patients for 30 months after their treatment to identify specific DNA changes that may increase their risk of death. By understanding these changes, researchers aim to uncover the mechanisms behind the heightened mortality rates in TB survivors. The approach combines patient follow-up with advanced genetic analysis to assess the impact of these epigenetic scars.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for TB survivors, potentially reducing their risk of long-term health complications and mortality.
How similar studies have gone: While other studies have explored the effects of epigenetic changes from various infections, this specific investigation into post-TB mortality is novel and has not been extensively studied.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Dinardo, Andrew R — Baylor College of Medicine
- Study coordinator: Dinardo, Andrew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.