The effects of maternal obesity on liver health in children
Maternal Obesity and Pediatric NAFLD: Fetal Origins and Long-term outcomes in Non Human Primates
This study looks at how being overweight during pregnancy can affect kids' liver health, specifically the risk of developing non-alcoholic fatty liver disease, by using a model that mimics human biology, and it hopes to find ways to help prevent liver problems in children of moms who are obese.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10875459 on NIH RePORTER |
What this research studies
This research investigates how maternal obesity influences the development of non-alcoholic fatty liver disease (NAFLD) in children, using a nonhuman primate model that closely resembles human physiology. The study examines the impact of a high-fat diet consumed by mothers during pregnancy and its long-term effects on their offspring's liver health. By analyzing liver tissue and metabolic responses, researchers aim to understand the mechanisms behind the increased risk of NAFLD in children born to obese mothers. This research could provide insights into early interventions to prevent liver disease in at-risk youth.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents who have a family history of obesity or liver disease.
Not a fit: Patients who are not affected by obesity or do not have a family history of liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing liver disease in children born to obese mothers.
How similar studies have performed: Previous research has shown that maternal diet can significantly affect offspring health, indicating that this approach may yield valuable insights.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Friedman, Jacob E — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Friedman, Jacob E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.