The effects of exercise on heart damage caused by a cancer drug.
Doxorubicin cardiotoxicity and the protective effects of exercise
This study is looking at how exercise might help protect your heart from damage while you're receiving doxorubicin, a common chemotherapy drug for cancer, and it aims to find ways to improve your heart health and overall well-being during treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10594901 on NIH RePORTER |
What this research studies
This research investigates how exercise can protect the heart from damage caused by doxorubicin, a common chemotherapy drug used to treat various cancers. The study focuses on understanding the mechanisms behind doxorubicin-induced cardiotoxicity and how endurance exercise may reduce the harmful accumulation of the drug in heart tissue. By exploring the relationship between exercise and heart health during cancer treatment, the research aims to identify strategies that could improve patient outcomes and quality of life. Patients participating in this research may engage in exercise programs designed to enhance their heart function while undergoing chemotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are scheduled to receive doxorubicin as part of their treatment regimen.
Not a fit: Patients who are not receiving doxorubicin or those with pre-existing severe heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health and quality of life for cancer patients receiving doxorubicin treatment.
How similar studies have performed: Previous research has shown promising results in using exercise to mitigate the side effects of chemotherapy, suggesting that this approach may be effective.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Smuder, Ashley — University of Florida
- Study coordinator: Smuder, Ashley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.