The effects of diet on lipoprotein(a) and oxidized phospholipids
Lp(a) and Oxidized Phospholipids - Impact of Diets
This study is looking at how cutting down on saturated fats in your diet affects a specific type of cholesterol called lipoprotein(a) [Lp(a)], which is important for heart health, especially for those who have high levels of it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10993651 on NIH RePORTER |
What this research studies
This research investigates how dietary changes, particularly the reduction of saturated fatty acids, impact levels of lipoprotein(a) [Lp(a)] and its associated oxidized phospholipids, which are linked to cardiovascular disease risk. The study aims to understand the paradoxical increase in Lp(a) levels when saturated fats are reduced, despite the benefits of such dietary changes for overall heart health. By exploring the mechanisms behind these changes, the research seeks to provide insights into how diet can be optimized to lower cardiovascular disease risk, particularly for individuals with elevated Lp(a).
Who could benefit from this research
Good fit: Ideal candidates for this research include adults, particularly those of African American descent, who have elevated levels of lipoprotein(a) and are at risk for cardiovascular disease.
Not a fit: Patients who do not have elevated lipoprotein(a) levels or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary guidelines that specifically address cardiovascular disease risk for individuals with high Lp(a) levels.
How similar studies have performed: While there have been limited studies on the dietary effects on Lp(a), this research aims to fill significant gaps in understanding, making it a novel approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Byambaa, Enkhmaa — University of California at Davis
- Study coordinator: Byambaa, Enkhmaa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.