The effects of artificial sweeteners on heart disease
Official title: Artificial sweeteners and cardiovascular disease
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11044452 · Data updated 2026-11-12
This study is looking at how low-calorie artificial sweeteners might affect heart health by causing inflammation in blood vessels, and it aims to help people understand the potential risks of these sweeteners for conditions like heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | March 4, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $796,395 |
| NIH project number | 1R01HL172805-01A1 |
| Project ID | NIH-11044452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who regularly consume artificial sweeteners and have risk factors for cardiovascular disease.
✕Less likely to help
Patients who do not consume artificial sweeteners or have no cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates how low-calorie artificial sweeteners may contribute to heart disease by increasing inflammation in blood vessels and promoting conditions like atherosclerosis. The study combines clinical observations with laboratory experiments using animal models to explore the relationship between these sweeteners and cardiovascular health. Researchers will analyze metabolites linked to heart disease risk and assess how these substances affect blood vessel function and clotting. Patients may be involved in providing data or samples to help understand these effects better.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of heart disease related to artificial sweetener consumption.
How similar studies have gone: There is growing epidemiological evidence questioning the benefits of artificial sweeteners, suggesting that this research could build on existing findings.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Hazen, Stanley L — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Hazen, Stanley L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.