TGF-ß-SOX18-Collagen metabolism and pulmonary vascular disease in CHD patients
Official title: TGF-ß-SOX18-Collagen metabolism in pulmonary vascular disease associated with CHD
Funded at Florida International University · NIH-11401963 · Data updated 2026-11-12
This project explores how the TGF-ß and SOX18 pathways affect lung blood vessels in people with congenital heart defects and abnormal blood flow.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | August 10, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $371,205 |
| NIH project number | 5P01HL146369-08 |
| Project ID | NIH-11401963 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adults with congenital heart defects causing increased pulmonary blood flow or pulmonary hypertension, and related patient-derived cells.
✕Less likely to help
Patients without CHD-related pulmonary vascular disease may not directly benefit from this research.
What this research studies
Researchers plan to study how SOX18 and related metabolism changes influence the growth and stiffness of lung blood vessels in the context of congenital heart defects. The work uses animal models and human cell data to understand the mechanisms driving vascular remodeling and disease progression. Findings could point toward new strategies to prevent or treat pulmonary hypertension in affected patients, including targeting transcription factors and metabolic pathways. The approach integrates molecular experiments with analysis of vascular changes relevant to patients with CHD and high pulmonary blood flow.
Why it matters
Potential benefit: If successful, the work could lead to new treatments that reduce lung vessel remodeling and pulmonary hypertension risk in CHD patients.
How similar studies have gone: Prior work shows that SOX18 and metabolic changes are linked to angiogenesis and vascular remodeling, supporting a plausible path to outcomes, though human translation remains developing.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Black, Stephen M — Florida International University
- Study coordinator: Black, Stephen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.