TET2's roles in blood stem cells and blood disorders
Dissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disorders
Looks at how different parts of the TET2 protein change blood stem cell behavior and contribute to blood disorders like myelodysplastic syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11239790 on NIH RePORTER |
What this research studies
This work aims to separate the enzyme activity of the TET2 protein from its other noncatalytic roles to understand how each supports healthy blood stem cells. Researchers use genetically engineered mice that either lack TET2 entirely or carry a version with only the enzyme activity disabled to compare outcomes. They study bone marrow, blood cell types, and molecular marks to see which defects lead to myeloid or lymphoid problems. The goal is to reveal mechanisms that could point toward better treatments for marrow failure and MDS.
Who could benefit from this research
Good fit: People with myelodysplastic syndrome or known TET2 mutations who might donate samples for related studies or be candidates for future clinical trials would be most relevant.
Not a fit: Patients without TET2 involvement or with unrelated conditions may not see direct or immediate benefits from this specific work.
Why it matters
Potential benefit: If successful, the research could reveal new molecular targets that guide development of better treatments for MDS and related blood disorders.
How similar studies have performed: Prior mouse studies have shown that losing TET2 can cause blood disorders, but dissecting catalytic versus noncatalytic functions is a newer approach that is less tested.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Ito, Keisuke — Albert Einstein College of Medicine
- Study coordinator: Ito, Keisuke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.