Testing safer somatic gene-editing using pig models
Genome Editing and Biological Effects Testing: Somatic Cell Gene Editing Testing
This project develops and tests gene-editing methods in pig models to help people with genetic conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11182509 on NIH RePORTER |
What this research studies
They create pig models that carry human genetic targets so researchers can test gene-editing tools before trying them in people. The Resource team breeds, validates, cryopreserves, and supplies these large-animal models to investigators. The Testing team runs standardized procedures to check safety and biological effects and produces detailed reports. A central coordination group preserves data and shares results to speed translation toward human therapies.
Who could benefit from this research
Good fit: People with inherited or somatic genetic conditions that might be treated by gene-editing therapies are the eventual beneficiaries of this work.
Not a fit: Patients without targetable genetic mutations or those needing immediate clinical treatment are unlikely to benefit directly from this resource-focused project.
Why it matters
Potential benefit: If successful, this work could make gene-editing treatments safer and more reliable for people with genetic diseases.
How similar studies have performed: Cell and small-animal gene-editing studies have shown promise, but standardized testing in large animals like pigs is less common and this resource fills a relatively novel translational gap.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Green, Jonathan a — University of Missouri-Columbia
- Study coordinator: Green, Jonathan a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.