Testing pravastatin to prevent preeclampsia in high-risk pregnant women
2/2: A Randomized Controlled Trial of Pravastatin for the Prevention of Preeclampsia in High Risk Women
This study is looking at whether taking pravastatin, a cholesterol-lowering medication, can help prevent preeclampsia in pregnant women who are at high risk for this condition, and it will involve a friendly trial where neither you nor the researchers will know if you’re getting the medication or a placebo.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10705625 on NIH RePORTER |
What this research studies
This research investigates whether pravastatin, a medication commonly used to lower cholesterol, can help prevent preeclampsia in women who are at high risk for this condition during pregnancy. The study will involve a multicenter, double-blind, placebo-controlled trial, meaning that neither the participants nor the researchers will know who receives the medication or a placebo. By administering pravastatin early in pregnancy, the researchers aim to assess its effectiveness in reducing the incidence of preeclampsia, which can lead to serious complications for both mothers and babies. Participants will be monitored throughout their pregnancy to evaluate the outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who have a history of preeclampsia or other risk factors that increase their likelihood of developing the condition.
Not a fit: Patients who are not pregnant or those who do not have any risk factors for preeclampsia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of preeclampsia, improving health outcomes for both mothers and their babies.
How similar studies have performed: Previous studies have shown promising results with statins in cardiovascular disease prevention, suggesting potential for success in this novel application for preeclampsia prevention.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Clifton, Rebecca Gersnoviez — George Washington University
- Study coordinator: Clifton, Rebecca Gersnoviez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.