Testing new treatments to protect the brain after a stroke
Official title: Testing Cerebroprotective Interventions with Rodent Ischemic Stroke Models
Funded at University of California, San Diego · NIH-11057715 · Data updated 2026-11-12
This study is looking at new ways to protect the brain during a stroke using animal models, which could help develop better treatments for people who have had a stroke.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $614,987 |
| NIH project number | 5U01NS130557-03 |
| Project ID | NIH-11057715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke and are seeking innovative treatment options.
✕Less likely to help
Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates potential cerebroprotective interventions using advanced animal models of ischemic stroke. By employing techniques such as the intraluminal middle cerebral artery occlusion (MCAO) and blood clot embolic models, the study aims to evaluate how these interventions can mitigate brain injury. The research team, with extensive experience in animal surgeries and stroke models, utilizes state-of-the-art facilities and equipment to monitor blood flow and assess brain function during and after the interventions. The findings could lead to improved strategies for protecting the brain in stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce brain damage and improve recovery outcomes for stroke patients.
How similar studies have gone: Previous research has shown promise in using similar cerebroprotective strategies in animal models, indicating potential for success in human applications.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hu, Bingren — University of California, San Diego
- Study coordinator: Hu, Bingren
Related research
Other NIH-funded projects on the same topics.
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Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
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EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
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Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
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How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
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Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.