Testing new treatments to protect the brain after a stroke
Official title: Duke Testing Site for Stroke Preclinical Assessment Network
Funded at Duke University · NIH-11004370 · Data updated 2026-11-12
This study is looking at new ways to protect the brain during treatment for people who have had an ischemic stroke, using animal models to find the best options before trying them in humans, all to help improve recovery for stroke patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $565,295 |
| NIH project number | 5U01NS130598-03 |
| Project ID | NIH-11004370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have suffered an ischemic stroke and are eligible for reperfusion therapy.
✕Less likely to help
Patients who have experienced hemorrhagic strokes or those who do not qualify for reperfusion therapy may not benefit from this research.
What this research studies
This research investigates effective cerebroprotective interventions that can be used alongside reperfusion therapy for patients who have experienced an ischemic stroke. By utilizing animal models, the study aims to assess the efficacy of these interventions in a controlled and blinded manner. The research is part of a larger initiative to improve long-term outcomes for stroke patients by identifying promising treatments before they are tested in humans. A multidisciplinary team at Duke University will conduct these assessments, leveraging their extensive experience in stroke research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and outcomes for stroke patients.
How similar studies have gone: Previous research has shown promise in developing cerebroprotective interventions, but this specific approach is part of a novel multi-site preclinical assessment initiative.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Sheng, Huaxin — Duke University
- Study coordinator: Sheng, Huaxin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.