Testing new treatments for breast cancer and overcoming drug resistance
Official title: Developing, Implementing and Supporting NCI Clinical Trials and the National Cancer Trials Network (NCTN) in Breast Cancer and Developmental Therapeutics- A 5 Year Plan
Funded at Mayo Clinic Rochester · NIH-10774501 · Data updated 2026-11-12
This study is all about finding better treatments for early-stage HER2-positive breast cancer, especially for those who don't respond to standard hormone therapies, and it invites patients to join in on exciting new trials that could help shape their care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 11, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $177,254 |
| NIH project number | 1R50CA278773-01A1 |
| Project ID | NIH-10774501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals diagnosed with endocrine-resistant or HER2-positive breast cancer.
✕Less likely to help
Patients with other types of breast cancer or those who are not HER2-positive may not benefit from this research.
What this research studies
This research focuses on developing and implementing clinical trials for breast cancer, particularly targeting endocrine-resistant and HER2-positive types. Led by Dr. Ciara O'Sullivan, the project aims to test new drugs and personalize treatment strategies for patients with early-stage HER2-positive breast cancer. The trials will involve collaboration with patient advocates to ensure that the needs and perspectives of patients are integrated into the research process. Patients may have the opportunity to participate in innovative trials that could lead to more effective treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with breast cancer.
How similar studies have gone: Previous research has shown success in developing targeted therapies for breast cancer, indicating a promising approach in this area.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: O'sullivan, Ciara — Mayo Clinic Rochester
- Study coordinator: O'sullivan, Ciara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.