Testing new tools for early detection of cognitive decline in Alzheimer's disease
Official title: Validation of the Mayo Test Drive Screening Battery Composite and Stricker Learning Span for Early Detection and Monitoring of Cognitive Decline in Preclinical and Prodromal Alzheimer’s Disease
Funded at Mayo Clinic Rochester · NIH-10988305 · Data updated 2026-11-12
This study is creating easy-to-use brain tests that you can take on your own devices to help spot early signs of memory problems related to Alzheimer's, so you can get the support you need sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,347,320 |
| NIH project number | 5R01AG081955-02 |
| Project ID | NIH-10988305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals showing early signs of cognitive decline or those at risk for Alzheimer's disease.
✕Less likely to help
Patients with advanced Alzheimer's disease or those who do not exhibit any cognitive impairment may not benefit from this research.
What this research studies
This research focuses on developing and validating cognitive assessment tools that can be easily accessed and used by patients to detect early signs of cognitive decline associated with Alzheimer's disease. The Mayo Test Drive platform allows for self-administration of cognitive tests on various devices, making it convenient for patients to participate. By identifying cognitive impairment early, the research aims to enable timely interventions that could slow down the progression of the disease. The study will also explore the integration of these cognitive assessments with biological markers to enhance diagnostic accuracy.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention for patients at risk of Alzheimer's disease, potentially improving their quality of life.
How similar studies have gone: Other research has shown promise in using digital cognitive assessments for early detection of cognitive decline, indicating that this approach may be effective.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Stricker, Nikki H — Mayo Clinic Rochester
- Study coordinator: Stricker, Nikki H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.