Testing new drug combinations for childhood soft tissue cancers
In Vivo Testing of Novel Drug Combinations for Pediatric Soft Tissue Sarcomas
['FUNDING_U01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10894935
This study is looking for better ways to treat children with soft tissue sarcomas by trying out new combinations of medicines on tumors grown in mice, with the hope of finding treatments that help kids live longer and feel better.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10894935 on ClinicalTrials.gov |
What this research studies
This research focuses on improving treatment outcomes for children with soft tissue sarcomas (STS) by testing novel drug combinations. The team uses patient-derived xenografts, which involve implanting tumor tissues from patients into mice to study how these tumors respond to different drugs. By integrating various research methods, including genomic and proteomic analyses, the goal is to identify effective therapies that can enhance survival rates and quality of life for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with soft tissue sarcomas, particularly those with recurrent disease.
Not a fit: Patients with soft tissue sarcomas who are older than 11 years or those with non-recurrent disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pediatric soft tissue sarcomas, improving survival rates and reducing long-term health burdens for survivors.
How similar studies have performed: Previous research has shown promise in using patient-derived xenografts for testing cancer treatments, indicating that this approach may lead to significant advancements in therapy.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DYER, MICHAEL A — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: DYER, MICHAEL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.