Testing macrolide antibiotics for treating pneumonia in children
Randomized Controlled Trial of Macrolide Therapy for Mycoplasma pneumoniae
This study is looking at whether adding azithromycin to standard antibiotics helps kids in the hospital with Mycoplasma pneumonia, so we can find out the best way to treat them and avoid giving them unnecessary medicine.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10620551 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of macrolide antibiotics, specifically azithromycin, in treating children hospitalized with Mycoplasma pneumoniae community-acquired pneumonia (CAP). The study will involve randomly assigning participants to receive either a combination of beta-lactam antibiotics and azithromycin or beta-lactam antibiotics with a placebo. By comparing these two groups, the research aims to provide clear evidence on the necessity and effectiveness of macrolide therapy, potentially reducing unnecessary antibiotic use and associated complications in pediatric patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who are hospitalized with community-acquired pneumonia caused by Mycoplasma pneumoniae.
Not a fit: Patients with pneumonia caused by other pathogens or those not requiring hospitalization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for children suffering from pneumonia, improving recovery rates and reducing hospital stays.
How similar studies have performed: Previous research has shown varying results regarding the effectiveness of macrolides for pneumonia, making this trial a critical step in determining their true benefit in pediatric cases.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Ambroggio, Lilliam — University of Colorado Denver
- Study coordinator: Ambroggio, Lilliam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.