Testing how well HIV can resist treatment from broadly neutralizing antibodies.
Detection Assays for Virion Susceptibility to HIV Broadly Neutralizing Antibodies in Plasma and Culture Fluids
This study is working on new tests to quickly find out if certain HIV strains can resist promising treatments called broadly neutralizing antibodies, so that only patients who can benefit from these therapies are included in clinical trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11057593 on NIH RePORTER |
What this research studies
This research focuses on developing new tests to quickly identify HIV variants that are resistant to broadly neutralizing antibodies (bnAbs), which are promising treatments for HIV/AIDS. The goal is to create innovative assays that can detect these resistant variants in patients before they enter clinical trials, ensuring that only those who can benefit from bnAb therapies are enrolled. By improving the accuracy and speed of these tests, the research aims to enhance the effectiveness of HIV treatment and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are considering participation in clinical trials for bnAb therapies.
Not a fit: Patients with HIV who do not have any resistant variants or who are not eligible for bnAb therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV treatments and better outcomes for patients by ensuring they receive therapies that are suitable for their specific viral strains.
How similar studies have performed: Previous research has shown promise in developing similar assays for detecting viral resistance, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Ray, Krishanu — University of Maryland Baltimore
- Study coordinator: Ray, Krishanu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.