Testing for antibodies to understand COVID-19 exposure and immunity

SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use

NIH-funded research Kaiser Foundation Research Institute · NIH-10688354

This study is looking for people who might have been exposed to the COVID-19 virus, even if they didn't show any symptoms, to see if they have developed antibodies, and it’s for anyone who is part of Kaiser Permanente Northern California.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionKaiser Foundation Research Institute NIH-funded
Lab location1 site (Oakland, UNITED STATES)
Project IDNIH-10688354 on NIH RePORTER

What this research studies

This research focuses on using serological testing to detect antibodies against SARS-CoV-2, the virus responsible for COVID-19. By identifying individuals who have been exposed to the virus, even if they were asymptomatic or did not undergo PCR testing, the study aims to provide a clearer picture of the virus's spread in the community. Participants will be recruited from Kaiser Permanente Northern California and will contribute to ongoing surveillance efforts to assess antibody development and immunity over time. The research will also analyze demographic and clinical data to better understand the factors influencing sero-prevalence and sero-incidence.

Who could benefit from this research

Good fit: Ideal candidates for participation include individuals aged 7 years and older who are members of Kaiser Permanente Northern California.

Not a fit: Patients who have not been exposed to SARS-CoV-2 or those who are not members of the Kaiser Permanente health system may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could enhance our understanding of COVID-19 immunity and inform public health strategies for managing the pandemic.

How similar studies have performed: Previous research has shown that serological testing can effectively identify past infections and contribute to understanding disease dynamics, making this approach promising.

Where this research is happening

Oakland, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cancersneoplasm/cancerCommunicable DiseasesInfectious Disease Pathway
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.