Testing cancer drugs using patient-derived organoid models
PREDICTIVE DRUG TESTING IN ORGANOID MODELS
This study is looking at how well different cancer drugs work using tiny lab-grown versions of tumors made from real patient samples, to help find the best treatments for individual patients based on their unique tumor characteristics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leidos Biomedical Research, INC. NIH-funded |
| Lab location | 1 site (Frederick, United States) |
| Project ID | NIH-11195485 on NIH RePORTER |
What this research studies
This research investigates how effective various approved and experimental cancer drugs are by using organoid models created from actual patient tumor tissues. By employing high-throughput screening techniques, the study aims to identify which tumors respond to specific drugs and to understand the mechanisms behind these responses. Additionally, it will explore how genetic changes in tumors affect drug efficacy and resistance, providing insights that could lead to more personalized cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with specific types of cancer who have tumor tissues available for organoid development.
Not a fit: Patients without tumor tissue samples or those with cancers not represented in the organoid models may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients based on their unique tumor characteristics.
How similar studies have performed: Other research has shown promise in using organoid models for drug testing, indicating that this approach could be effective.
Where this research is happening
Frederick, United States
- Leidos Biomedical Research, INC. — Frederick, United States (Active)
Researchers
- Principal investigator: Dmitrovsky, Ethan — Leidos Biomedical Research, INC.
- Study coordinator: Dmitrovsky, Ethan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.