Testing cancer drugs using patient-derived organoid models
PREDICTIVE DRUG TESTING IN ORGANOID MODELS
This study is looking at how well different cancer drugs work by testing them on tiny models made from real patient tumors, so we can find out which treatments might be best for you based on your unique cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leidos Biomedical Research, INC. NIH-funded |
| Lab location | 1 site (Frederick, United States) |
| Project ID | NIH-10281352 on NIH RePORTER |
What this research studies
This research investigates how effective various cancer drugs are by using organoid models created from actual patient tumor tissues. By employing high-throughput screening techniques, the study aims to identify which tumors respond to specific drugs and to understand the mechanisms behind these responses. Additionally, it will explore predictive biomarkers that indicate how well a patient might respond to treatment, as well as the impact of genetic changes on drug effectiveness. This approach allows for a more personalized treatment strategy for cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that can be used to create organoid models, particularly those with specific genetic alterations.
Not a fit: Patients without tumors or those whose tumors cannot be cultured into organoids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients.
How similar studies have performed: Other research has shown promise in using organoid models for drug testing, indicating that this approach could be effective.
Where this research is happening
Frederick, United States
- Leidos Biomedical Research, INC. — Frederick, United States (Active)
Researchers
- Principal investigator: Dmitrovsky, Ethan — Leidos Biomedical Research, INC.
- Study coordinator: Dmitrovsky, Ethan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.