Testing a new way to deliver chemotherapy for colorectal cancer with peritoneal metastasis.
Official title: A phase-1 trial of intraperitoneal 5-fluorouracil and oxaliplatin in patients with colorectal cancer and unresectable peritoneal metastasis.
Funded at Ohio State University · NIH-10722263 · Data updated 2026-11-12
This study is looking at a new way to give chemotherapy directly to the belly for people with colorectal cancer that has spread there, to see if it works better and is safe for those who can’t have surgery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 12, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $336,425 |
| NIH project number | 1R21CA282536-01 |
| Project ID | NIH-10722263 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with colorectal cancer who have unresectable peritoneal metastasis and a peritoneal carcinomatosis index of less than 20.
✕Less likely to help
Patients with colorectal cancer that is resectable or those with extensive peritoneal metastasis may not benefit from this research.
What this research studies
This research investigates the use of intraperitoneal chemotherapy with 5-fluorouracil and oxaliplatin for patients suffering from colorectal cancer that has spread to the peritoneum. The approach aims to deliver chemotherapy directly to the affected area, potentially improving drug concentration and effectiveness compared to traditional intravenous methods. The study will assess the feasibility and safety of this treatment in patients who are not candidates for surgery. By focusing on a specific patient population with limited disease, the research seeks to provide a new therapeutic option for those with poor outcomes.
Why it matters
Potential benefit: If successful, this research could offer a more effective treatment option for patients with colorectal cancer and peritoneal metastasis, potentially improving survival rates.
How similar studies have gone: While small pilot studies in the past have shown promise for intraperitoneal chemotherapy, this research represents a systematic approach to assess its feasibility in a modern context.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Mittra, Arjun — Ohio State University
- Study coordinator: Mittra, Arjun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.