Testing a new urine test for detecting diabetes during pregnancy
Official title: Urine levels of Glycated CD59 for screening and diagnosis of pregnancy-induced glucose intolerance
Funded at Brigham and Women's Hospital · NIH-11060961 · Data updated 2026-11-12
This study is testing a new urine test that looks for a marker called glycated CD59 to see if it can help identify gestational diabetes more easily and affordably than the usual glucose tests, aiming to improve health for moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $647,442 |
| NIH project number | 5R01DK136617-02 |
| Project ID | NIH-11060961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women who are at risk for developing glucose intolerance.
✕Less likely to help
Patients who are not pregnant or those who do not have risk factors for gestational diabetes may not benefit from this research.
What this research studies
This research aims to validate a new biomarker, glycated CD59 (GCD59), found in urine, as a tool for screening and diagnosing pregnancy-induced glucose intolerance, also known as gestational diabetes. The study will assess the effectiveness of this biomarker in various hyperglycemic conditions, focusing on its potential to provide a simpler and more cost-effective alternative to traditional glucose load tests. By improving the screening process, the research seeks to enhance the health outcomes for both mothers and their newborns by identifying those at risk of complications earlier and more accurately.
Why it matters
Potential benefit: If successful, this research could lead to a more accessible and efficient method for diagnosing gestational diabetes, ultimately improving maternal and fetal health outcomes.
How similar studies have gone: Previous research has shown promise in using novel biomarkers for diabetes detection, indicating potential success for this approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Halperin, Jose a — Brigham and Women's Hospital
- Study coordinator: Halperin, Jose a
Related research
Other NIH-funded projects on the same topics.
-
How air pollution during pregnancy affects fetal growth over time
This study looks at how air pollution affects the growth of babies in the womb during pregnancy, using ultrasound images to track changes over time, and it aims to help expectant parents understand when their babies might be most at risk from pollution.
-
Postoperative Pain Guidelines for Pregnancy: Safer, Patient-Centered Opioid Use
We’re creating patient-friendly guidelines to help doctors manage pain after delivery and surgery in pregnant people, aiming to reduce opioid overuse and improve safety.
-
HPV and pregnancy risk: a big study following 1,280 pregnancies
A large pregnancy study at UTMB looks at whether human papillomavirus (HPV) during pregnancy is linked to problems like preterm birth.
-
Understanding how where you live and personal factors during pregnancy affect a child’s risk for obesity and metabolic problems
This project looks at how neighborhood conditions and individual factors during pregnancy may influence a child’s risk of obesity and metabolic health as they grow.
-
Blocking cancer-causing cMYC tricks after pregnancy changes in the breast
Researchers are testing how pregnancy and aging reshape the breast before cancer risk, using patient-reinformed models to see if it changes how dangerous cMYC signals behave.
-
SSRI use during pregnancy: effects on placental blood flow and inflammation
This grant studies how antidepressants (SSRIs) used during pregnancy might affect the placenta and inflammation, and whether a 5-HT2 receptor blocker could mitigate any negative effects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.