Testing a new treatment to improve heart health in patients starting hemodialysis
Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation
This study is looking at whether a combination of two heart medications, sacubitril and valsartan, can help improve heart health and protect kidney function in people who are just starting hemodialysis for advanced kidney failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10771276 on NIH RePORTER |
What this research studies
This research investigates the effects of a combination therapy using sacubitril and valsartan on patients who are beginning hemodialysis due to advanced kidney failure. The study aims to determine if this treatment can improve heart health and preserve kidney function in these patients, who are at high risk for cardiovascular issues. Participants will be randomly assigned to receive either the treatment or a placebo, and their heart and kidney health will be monitored over time. The goal is to find a safer and more effective way to manage the health of patients starting hemodialysis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are initiating hemodialysis due to advanced kidney failure and have cardiovascular concerns.
Not a fit: Patients who are not starting hemodialysis or those without cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health and better kidney function for patients starting hemodialysis.
How similar studies have performed: Previous studies have shown that similar therapies can improve cardiovascular outcomes in other patient populations, suggesting potential for success in this group.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mccausland, Finnian R — Brigham and Women's Hospital
- Study coordinator: Mccausland, Finnian R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.