Testing a new treatment to improve heart health in patients starting hemodialysis
Official title: Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation
Funded at Brigham and Women's Hospital · NIH-10771276 · Data updated 2026-11-12
This study is looking at whether a combination of two heart medications, sacubitril and valsartan, can help improve heart health and protect kidney function in people who are just starting hemodialysis for advanced kidney failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2022 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $343,680 |
| NIH project number | 5R01DK129749-03 |
| Project ID | NIH-10771276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are initiating hemodialysis due to advanced kidney failure and have cardiovascular concerns.
✕Less likely to help
Patients who are not starting hemodialysis or those without cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the effects of a combination therapy using sacubitril and valsartan on patients who are beginning hemodialysis due to advanced kidney failure. The study aims to determine if this treatment can improve heart health and preserve kidney function in these patients, who are at high risk for cardiovascular issues. Participants will be randomly assigned to receive either the treatment or a placebo, and their heart and kidney health will be monitored over time. The goal is to find a safer and more effective way to manage the health of patients starting hemodialysis.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health and better kidney function for patients starting hemodialysis.
How similar studies have gone: Previous studies have shown that similar therapies can improve cardiovascular outcomes in other patient populations, suggesting potential for success in this group.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Mccausland, Finnian R — Brigham and Women's Hospital
- Study coordinator: Mccausland, Finnian R
Related research
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-
StepNet-Adapt: a personalized mobile program to boost activity for people on dialysis
A personalized mobile health program uses wearables, texts, and coaching to help people on hemodialysis become more physically active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.