Testing a new treatment to ease opioid withdrawal symptoms.
Preclinical assessment of a Sterol Carrier Protein-2 inhibitor in multidimensional opioid withdrawal.
This study is exploring a new way to help people dealing with opioid withdrawal symptoms like pain and anxiety by using a special treatment that might make the body’s natural calming substances work better, aiming to offer a safer option for those facing opioid use challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11064238 on NIH RePORTER |
What this research studies
This research investigates a novel approach to alleviate the symptoms of opioid withdrawal, which can include pain, anxiety, and irritability. The study focuses on a specific inhibitor that targets a protein involved in the transport of endocannabinoids, potentially enhancing their effects without the side effects associated with traditional cannabinoid treatments. Using a preclinical model, the research will assess how this inhibitor can improve the management of withdrawal symptoms in a controlled setting. The findings could lead to new therapeutic options for individuals struggling with opioid use disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing opioid withdrawal symptoms, particularly those with opioid use disorder.
Not a fit: Patients who are not currently experiencing opioid withdrawal or those not diagnosed with opioid use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for managing opioid withdrawal symptoms.
How similar studies have performed: Previous research has shown promise in using cannabinoid-related approaches for managing withdrawal symptoms, making this a potentially impactful area of exploration.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Moore, Catherine Frances — Johns Hopkins University
- Study coordinator: Moore, Catherine Frances
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.