Testing a new therapy to reduce damage from spinal cord injuries
Official title: Preclinical evaluation of efficacy and safety of a new iron chelator therapy in chronic spinal cord injury
Funded at Veterans Health Administration · NIH-10909845 · Data updated 2026-11-12
This study is testing a new treatment that helps reduce damage from iron buildup after spinal cord injuries, especially for those affected by battlefield incidents, to see if it can improve recovery and movement in patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01RX003986-03 |
| Project ID | NIH-10909845 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals who have experienced cervical spinal cord injuries, particularly those with ongoing disabilities.
✕Less likely to help
Patients with spinal cord injuries not related to hemorrhage or those with acute injuries may not benefit from this research.
What this research studies
This research investigates a new iron chelator therapy aimed at treating cervical spinal cord injuries (C-SCI), which often result from battlefield incidents. The study will evaluate the safety and effectiveness of this therapy, SP420, in combination with a locomotor therapy in a rodent model. By targeting the oxidative stress and inflammation caused by iron deposits from hemorrhage, the research seeks to improve recovery and function in spinal cord injury cases. The goal is to develop a treatment that can be translated into clinical use for patients suffering from these injuries.
Why it matters
Potential benefit: If successful, this research could lead to a new therapeutic option that significantly improves recovery and quality of life for patients with spinal cord injuries.
How similar studies have gone: While the approach of using iron chelation in spinal cord injury is novel, similar strategies targeting oxidative stress have shown promise in other neurological conditions.
Where this research is happening
-
Veterans Health Administration
Gainesville, United States Active
Researchers
- Principal investigator: Bose, Prodip K. — Veterans Health Administration
- Study coordinator: Bose, Prodip K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.