Testing a new oral treatment for Alzheimer's disease
A Proof of Concept Trial of a Sirtuin-NAD+ Activator in Alzheimer's Disease
This study is looking at how a special compound called βNMN might help people with mild Alzheimer's by boosting brain health, and it will involve 24 participants taking either the compound or a placebo for 90 days while researchers check how well it works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10634622 on NIH RePORTER |
What this research studies
This research investigates the effects of a compound called β nicotinamide mononucleotide (βNMN) on Alzheimer's disease by enhancing the sirtuin-NAD+ pathway, which is involved in aging and neuroprotection. The study will involve a 90-day trial with 24 participants who have mild Alzheimer's dementia, where they will receive either the treatment or a placebo in a double-blind manner. Researchers will use advanced imaging techniques to measure how well the drug penetrates the blood-brain barrier and increases NAD levels in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with mild Alzheimer's dementia.
Not a fit: Patients with severe Alzheimer's disease or other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new oral treatment that slows the progression of Alzheimer's disease and improves brain health.
How similar studies have performed: While NAD precursors have shown promise in preclinical models, this specific approach in humans is novel and has not been extensively tested.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bhasin, Shalender — Brigham and Women's Hospital
- Study coordinator: Bhasin, Shalender
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.