Testing a new drug to help treat opioid use disorder
Preclinical and clinical evaluation of the NMDA modulator NYX-783 for OUD
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10635746
This study is looking at a new medication called NYX-783 to see if it can help people with opioid addiction by making it easier for them to resist the urge to use opioids, and it will involve both animal tests and human trials to check how safe and effective it is.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10635746 on ClinicalTrials.gov |
What this research studies
This research investigates the NMDA modulator NYX-783 as a potential treatment for opioid use disorder (OUD). It involves both preclinical studies in animal models and clinical trials in humans to assess the drug's safety, tolerability, and effectiveness in reducing opioid-seeking behavior. The study will evaluate NYX-783 alone and in combination with oxycodone to ensure it is safe for patients. If successful, this research could lead to new therapeutic options for individuals struggling with opioid addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who are seeking treatment.
Not a fit: Patients who are not struggling with opioid use disorder or those who are not interested in participating in clinical trials may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients with opioid use disorder, potentially reducing cravings and relapse rates.
How similar studies have performed: Previous research has shown promise in using NMDA modulators for addiction treatment, but this specific approach with NYX-783 is novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINHA, RAJITA — YALE UNIVERSITY
- Study coordinator: SINHA, RAJITA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.