Testing a new drug target to treat right ventricular failure
Validation of a novel drug target to treat RV failure
This study is looking at a new drug called A61603 to see if it can help people with right ventricular failure, a heart condition often caused by high blood pressure in the lungs, by improving heart function and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11047650 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treating right ventricular failure (RVF), a serious condition often linked to pulmonary hypertension. The study focuses on the effects of a specific drug, A61603, which targets the alpha-1A-adrenergic receptor to improve heart function. By using a model that mimics the disease, researchers will assess how this drug can enhance heart muscle performance, increase exercise capacity, and reduce cell damage. Patients may benefit from a new treatment option that could significantly improve their quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with right ventricular failure, particularly those with underlying conditions such as pulmonary hypertension.
Not a fit: Patients with isolated left ventricular failure or those without any form of heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for patients suffering from right ventricular failure.
How similar studies have performed: Preliminary studies have shown promising results with similar approaches, indicating that targeting the alpha-1A-adrenergic receptor may effectively treat RVF.
Where this research is happening
San Francisco, United States
- Veterans Affairs Med Ctr San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Baker, Anthony J. — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Baker, Anthony J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.