Testing a new drug target to treat right ventricular failure
Official title: Validation of a novel drug target to treat RV failure
Funded at Veterans Affairs Med Ctr San Francisco · NIH-11047650 · Data updated 2026-11-12
This study is looking at a new drug called A61603 to see if it can help people with right ventricular failure, a heart condition often caused by high blood pressure in the lungs, by improving heart function and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 1I21BX006858-01 |
| Project ID | NIH-11047650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with right ventricular failure, particularly those with underlying conditions such as pulmonary hypertension.
✕Less likely to help
Patients with isolated left ventricular failure or those without any form of heart failure may not benefit from this research.
What this research studies
This research investigates a novel approach to treating right ventricular failure (RVF), a serious condition often linked to pulmonary hypertension. The study focuses on the effects of a specific drug, A61603, which targets the alpha-1A-adrenergic receptor to improve heart function. By using a model that mimics the disease, researchers will assess how this drug can enhance heart muscle performance, increase exercise capacity, and reduce cell damage. Patients may benefit from a new treatment option that could significantly improve their quality of life.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for patients suffering from right ventricular failure.
How similar studies have gone: Preliminary studies have shown promising results with similar approaches, indicating that targeting the alpha-1A-adrenergic receptor may effectively treat RVF.
Where this research is happening
-
Veterans Affairs Med Ctr San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Baker, Anthony J. — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Baker, Anthony J.
Related research
Other NIH-funded projects on the same topics.
-
Predicting TBI-Related Brain and Eye Pathology with Blood and Retina Biomarkers
A multi-site study aims to find biomarkers in blood and the retina that forecast long-term brain damage after traumatic brain injury, using both animal models and human samples.
-
Gut microbes and methotrexate: boosting RA treatment through microbiome targets
Researchers are studying how gut bacteria affect how well methotrexate works for people with rheumatoid arthritis, aiming to make MTX effective for more patients.
-
Precision medicine for elderly veterans with chronic inflammatory skin disease
Aimed at understanding and tailoring treatments for older adults with eczema-like skin inflammation (atopic dermatitis) among veterans.
-
PTSD and Autoimmune Diseases: How PTSD Might Cause or Change Risk and What Might Help
This project looks at whether PTSD in Veterans affects the risk of autoimmune diseases and whether there are factors that influence that risk.
-
Chromatin clues to how neural stem cells grow into specific brain cells
A study exploring how a chromatin regulator shapes neural stem cells to make the right brain cells, with potential relevance to neurological conditions affecting adults.
-
Vaccine failure after Covid-19 vaccination in older adults
This project follows vaccinated older adults to understand who among them still gets Covid-19 and what factors make those outcomes worse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.