Testing a mouse model to understand HIV-related cognitive issues and treatments
Validating a Humanized Mouse HIV Model for Cognitive Deficits and Novel Treatments
This study is looking at how HIV can affect thinking and memory in people living with the virus, especially those on treatment, by using special mice that act like humans to find better ways to help prevent these issues from getting worse.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project ID | NIH-10948928 on NIH RePORTER |
What this research studies
This research investigates the use of a humanized mouse model to study HIV-associated neurocognitive disorders (HAND), which affect many individuals living with HIV. The approach focuses on understanding cognitive deficits that occur in patients, particularly those on antiretroviral therapy, and aims to develop new treatment strategies before these deficits progress to dementia. By using a mouse model that closely mimics human conditions, researchers can explore the long-term effects of potential treatments and better understand the disease's pathology. This model will help identify effective interventions for patients experiencing mild forms of HAND.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing mild cognitive deficits.
Not a fit: Patients who do not have HIV or those who are already experiencing advanced dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that stabilize or reverse cognitive deficits in individuals living with HIV.
How similar studies have performed: Previous research has shown promise in using animal models to study HIV-related cognitive disorders, indicating that this approach could yield valuable insights.
Where this research is happening
Decatur, UNITED STATES
- Veterans Health Administration — Decatur, United States (Active)
Researchers
- Principal investigator: Tyor, William R — Veterans Health Administration
- Study coordinator: Tyor, William R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.