Testing a medication to help adults quit using e-cigarettes
Official title: Investigating Efficacious E-Cigarette Interventions and Cessation Effects on Cancer-Related Biomarkers: A Randomized Trial of Varenicline in Adults
Funded at Yale University · NIH-11022368 · Data updated 2026-11-12
This study is looking at how well the medication varenicline can help adults who only use e-cigarettes quit, and it involves a friendly group of participants who will either take the medication or a placebo to see what works best.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $687,995 |
| NIH project number | 1R01CA296186-01 |
| Project ID | NIH-11022368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 18 and older who use e-cigarettes daily and are seeking to quit.
✕Less likely to help
Patients who do not use e-cigarettes or are under 18 years old may not benefit from this research.
What this research studies
This research investigates the effectiveness of varenicline, a medication commonly used for smoking cessation, in helping adults who exclusively use e-cigarettes to quit. The study will involve a randomized clinical trial with 326 participants aged 18 and older, some of whom may have a history of cigarette smoking. Participants will receive either varenicline or a placebo, and their progress will be monitored to assess changes in cancer-related biomarkers and cessation rates. The goal is to provide evidence-based methods for e-cigarette cessation, addressing a growing public health concern.
Why it matters
Potential benefit: If successful, this research could provide a proven method for adults to quit e-cigarettes, potentially reducing cancer risk and improving overall health.
How similar studies have gone: Previous studies have shown promising results for varenicline in smoking cessation, suggesting potential success for its use in e-cigarette cessation as well.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Fucito, Lisa M — Yale University
- Study coordinator: Fucito, Lisa M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.