TEDDY follow-up and new nested case-control group on environmental causes of childhood type 1 diabetes
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
['FUNDING_U01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11388397
This project keeps tracking children in the TEDDY study and adds a new nested case-control group to learn whether environmental exposures relate to early-onset type 1 diabetes.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11388397 on ClinicalTrials.gov |
What this research studies
If your child is in the TEDDY group, this project continues regular follow-up visits, data collection, and secure handling of medical and lab information. The Data Coordinating Center at the University of South Florida will collect, manage, and analyze data sent from TEDDY clinical sites and monitor data quality and protocol adherence. The team will start a second nested case-control cohort to compare children who develop diabetes-related autoantibodies or diabetes with matched participants who do not, looking for environmental differences. The project also supports communications, study documents, and a website so families can stay informed.
Who could benefit from this research
Good fit: Ideal candidates are children already enrolled in the TEDDY cohort or families with children at increased genetic risk who can continue scheduled follow-up and sample collection.
Not a fit: Patients who are not part of TEDDY, who have unrelated types of diabetes (for example, typical adult type 2 diabetes), or who seek immediate treatment changes are unlikely to get direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help identify environmental triggers of childhood type 1 diabetes and support earlier detection or prevention strategies.
How similar studies have performed: Earlier TEDDY results and other cohort studies have found some links between environment and type 1 diabetes risk, and nested case-control analyses are a common, established method to probe those links further.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRISCHER, JEFFREY P — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: KRISCHER, JEFFREY P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brittle Diabetes Mellitus