Targeting tumor growth and spread in aggressive breast cancers with centrosome amplification
Inhibiting tumor growth and metastasis in highly aggressive breast cancers with centrosome amplification
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-10867312
This study is looking at how having too many centrosomes in breast cancer cells can make the cancer grow and spread, and it’s testing a way to block a protein called TACC3 to help kill these cancer cells and stop them from moving into other tissues, which could lead to new treatments for patients with aggressive breast cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10867312 on ClinicalTrials.gov |
What this research studies
This research investigates how centrosome amplification, a condition where cells have extra centrosomes, contributes to the growth and spread of aggressive breast cancers. The approach focuses on inhibiting a specific protein, TACC3, which is involved in the clustering of centrosomes during cell division. By disrupting this process, the research aims to induce cell death in cancer cells and prevent their migration and invasion into surrounding tissues. Patients may benefit from new treatment strategies that specifically target these aggressive cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with aggressive forms of breast cancer, particularly those exhibiting centrosome amplification.
Not a fit: Patients with non-aggressive breast cancer or those without centrosome amplification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with aggressive breast cancers, potentially improving survival rates.
How similar studies have performed: Other research has shown promising results in targeting centrosome amplification in various cancers, suggesting that this approach may be effective.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAHIN, OZGUR — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: SAHIN, OZGUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.