Targeting tumor cells in prostate cancer that spread to bone
Official title: Drug Mechanism of Action-based targeting of tumor subpopulations
Funded at Columbia University Health Sciences · NIH-11179583 · Data updated 2026-11-12
This study is looking at how prostate cancer spreads to the bones and how these cancer cells react to different treatments, with the goal of finding better ways to help patients who have prostate cancer that has spread.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $164,500 |
| NIH project number | 3U54CA274506-02S1 |
| Project ID | NIH-11179583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic prostate cancer, particularly those with bone involvement.
✕Less likely to help
Patients with localized prostate cancer that has not spread to the bone may not benefit from this research.
What this research studies
This research investigates how prostate cancer cells spread to bone and how they respond to treatments. Using advanced models and technologies, the team aims to understand the unique characteristics of these tumor cells and their interactions with the bone environment. By identifying the mechanisms that drive bone metastasis, the research seeks to improve treatment strategies for patients with metastatic prostate cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for prostate cancer that has spread to the bone.
How similar studies have gone: Previous research has shown promise in targeting tumor heterogeneity in metastatic cancers, suggesting potential for success in this approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Califano, Andrea — Columbia University Health Sciences
- Study coordinator: Califano, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.