Targeting the supportive tissue in pancreatic cancer treatment
Targeting the Stroma for Pancreatic Cancer Treatment
This study is looking at how to make treatments better for pancreatic cancer by understanding the supportive tissue around the tumor, with the goal of improving immunotherapy and helping patients have better outcomes after surgery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11051239 on NIH RePORTER |
What this research studies
This research investigates how to improve treatment for pancreatic ductal adenocarcinoma (PDAC) by focusing on the tumor's surrounding supportive tissue, known as the stroma. It aims to enhance the effectiveness of immunotherapy, which has shown success in other cancers but struggles in PDAC due to the tumor's unique environment. By analyzing the tumor microenvironment before surgery, the research seeks to identify ways to make treatments more effective and reduce the chances of cancer returning after surgery. The approach combines clinical insights with laboratory research to develop new strategies for patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing neoadjuvant treatment before surgery.
Not a fit: Patients with other types of cancer or those who are not candidates for surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting the tumor microenvironment in other cancers, suggesting that this approach may also be beneficial for pancreatic cancer.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Osipov, Arsen — Cedars-Sinai Medical Center
- Study coordinator: Osipov, Arsen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.