Targeting the supportive environment of follicular lymphoma
Towards targeting the lymphoma microenvironment
This study is looking at how the environment around follicular lymphoma affects its growth and treatment, with the goal of finding new ways to make existing therapies work better for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10896437 on NIH RePORTER |
What this research studies
This research focuses on understanding how the microenvironment surrounding follicular lymphoma (FL) affects the growth and treatment of this slow-growing cancer. The team aims to disrupt the interactions within this supportive niche, which may protect malignant B cells and contribute to the disease's progression and resistance to therapies. By utilizing advanced mouse models and studying genetic mutations, the researchers hope to identify new therapeutic strategies that could enhance the effectiveness of existing treatments for FL. Patients may benefit from insights that lead to more effective therapies tailored to their specific cancer biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with follicular lymphoma, particularly those who have not responded well to standard therapies.
Not a fit: Patients with aggressive forms of lymphoma that do not share the same microenvironment characteristics as follicular lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with follicular lymphoma, potentially making previously ineffective therapies more effective.
How similar studies have performed: Previous research has shown promise in targeting the microenvironment in other types of cancers, suggesting that this approach may also be effective for follicular lymphoma.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Wendel, Hans-Guido — Sloan-Kettering Inst Can Research
- Study coordinator: Wendel, Hans-Guido
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.