Targeting the sphingosine-1-phosphate system to treat ALS
Sphingosine-1-phosphate system as a therapeutic target for amyotrophic lateral sclerosis
This study is looking at how certain fats in the body and the immune system might affect the progression of ALS, a serious disease that causes muscle weakness, and it hopes to find new treatment options that could help slow down the disease for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10911026 on NIH RePORTER |
What this research studies
This research investigates the role of the sphingosine-1-phosphate system in amyotrophic lateral sclerosis (ALS), a severe neurological disease that leads to muscle weakness and paralysis. The study focuses on understanding how lipid metabolism and immune system dysfunction contribute to the progression of ALS. By exploring the interactions between motor neurons and surrounding non-neuronal cells, the research aims to identify potential therapeutic targets that could slow down or halt disease progression. Patients may be involved in trials assessing new treatments derived from these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis at various stages of the disease.
Not a fit: Patients with other neurological disorders or those who do not have a diagnosis of ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the quality of life and extend survival for ALS patients.
How similar studies have performed: Previous research has shown promise in targeting lipid metabolism and immune responses in ALS, suggesting that this approach could yield significant advancements.
Where this research is happening
Boston, United States
- VA Boston Health Care System — Boston, United States (Active)
Researchers
- Principal investigator: Dedeoglu, Alpaslan — VA Boston Health Care System
- Study coordinator: Dedeoglu, Alpaslan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.