Targeting the resistance of glioblastoma stem cells to improve treatment outcomes
Official title: Targeting Malignant Reprogramming of Glioblastoma Stem Cells Through Dual Inhibition of S6K1 and BIRC3
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11002301 · Data updated 2026-11-12
This study is looking at new ways to treat glioblastoma, a tough brain cancer, by focusing on the stem cells that help it grow and resist treatment, with the hope of finding better therapies that could help patients live longer and feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | December 19, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $541,074 |
| NIH project number | 5R01NS135220-02 |
| Project ID | NIH-11002301 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research focuses on glioblastoma, a highly aggressive brain cancer that is often resistant to current treatments. The team aims to develop new therapies that specifically target the malignant reprogramming of glioblastoma stem cells, which contribute to the cancer's lethality. By investigating the interactions between specific proteins involved in cancer cell survival and resistance, the researchers hope to identify effective strategies to prevent the evolution of these cells into more aggressive forms. Patients may benefit from innovative treatments that could enhance survival rates and improve quality of life.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with glioblastoma.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in glioblastoma, indicating potential for success in this approach.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Etame, Arnold — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Etame, Arnold
Related research
Other NIH-funded projects on the same topics.
-
Small molecules to block Slit2/ROBO in glioblastoma
A study to test small molecule drugs that block Slit2/ROBO signals to help treat glioblastoma in patients.
-
Immunotherapy for glioblastoma: advancing treatment and understanding
A patient-friendly summary of a grant exploring new immune-based treatments for glioblastoma to improve options for people affected by this brain cancer.
-
Small-molecule and biologic treatments for glioblastoma using targeted brain delivery
A new approach aims to use FPS-ZM1 to shrink brain swelling and support immunotherapy for glioblastoma, potentially helping patients recover after surgery.
-
Targeted therapies for glioblastoma in adults and kids
A large NIH program is exploring new brain cancer therapies, including drugs that reach the brain and work against glioblastoma in both children and adults.
-
6-thio-2'-deoxyguanosine for glioblastoma: a new approach to target tumors before surgery
A trial tests a novel drug given before glioblastoma surgery to see how it behaves in the body and within the tumor, and to learn how it affects cancer cells and the immune environment.
-
CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma
A patient-facing look at how scientists plan to study how glioblastoma grows by changing its metabolism and dampening the immune response, with potential targets to help treatment in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.