Targeting the hepatitis B virus in patients with both HBV and HIV infections
Targeting hepatitis B virus cccDNA during HBV/HIV co-infection
This study is looking for new ways to help people who have both hepatitis B and HIV by finding better treatments to fight the hepatitis B virus and improve liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-10837998 on NIH RePORTER |
What this research studies
This research focuses on patients who are co-infected with hepatitis B virus (HBV) and human immunodeficiency virus (HIV). It aims to develop new therapeutic approaches to combat chronic HBV infection, particularly in the context of HIV, which can worsen liver disease. The researchers will explore innovative methods to interfere with the persistent HBV infection by targeting the cccDNA, a crucial component for the virus's replication. By leveraging recent breakthroughs in their lab, they hope to establish proof-of-concept for these new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with both hepatitis B and HIV infections.
Not a fit: Patients who are solely infected with HIV or HBV without co-infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective therapies that significantly improve liver health and overall outcomes for patients co-infected with HBV and HIV.
How similar studies have performed: While there have been advancements in treating HBV and HIV separately, this approach targeting cccDNA in co-infected patients is novel and has not been extensively tested.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Ploss, Alexander — Princeton University
- Study coordinator: Ploss, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.