Targeting the different states of glioblastoma tissue
Official title: MOSAIC: Targeting the Tissue State
Funded at Mayo Clinic Arizona · NIH-11186082 · Data updated 2026-11-12
This study is looking at how different cells in glioblastoma, a tough type of brain cancer, work together and affect treatment, with the goal of finding better ways to help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $12,590 |
| NIH project number | 3U54CA274504-02S1 |
| Project ID | NIH-11186082 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing treatment.
✕Less likely to help
Patients with other types of brain tumors or those who are not currently receiving treatment for glioblastoma may not benefit from this research.
What this research studies
This research investigates glioblastoma (GBM), a type of brain cancer characterized by its diverse cellular makeup, which complicates treatment. The project aims to understand how various tumor and non-tumor cells interact within the tumor microenvironment, influencing tumor growth and response to therapies. By analyzing the cellular composition and the signals exchanged between these cells, researchers hope to identify new therapeutic strategies. The study utilizes advanced techniques like single nucleus RNA sequencing to explore changes in tissue states before and after treatment.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma by targeting its unique cellular environments.
How similar studies have gone: Previous research has shown promise in understanding tumor microenvironments, suggesting that this approach could lead to significant advancements in glioblastoma treatment.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Tran, Nhan L — Mayo Clinic Arizona
- Study coordinator: Tran, Nhan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.