Targeting the different states of glioblastoma tissue
Official title: MOSAIC: Targeting the Tissue State
Funded at Mayo Clinic Arizona · NIH-10930913 · Data updated 2026-11-12
This study is looking at how different types of cells in glioblastoma, a kind of brain cancer, work together and change during treatment, with the hope of finding better ways to help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $326,244 |
| NIH project number | 5U54CA274504-02 |
| Project ID | NIH-10930913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing treatment.
✕Less likely to help
Patients with other types of brain tumors or those not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research investigates the complex cellular environment of glioblastoma, a type of brain cancer, which is characterized by diverse cell types and behaviors. By analyzing the interactions between tumor cells and surrounding non-tumor cells, the study aims to identify unique cellular compositions and their roles in tumor growth and treatment resistance. Using advanced techniques like single nucleus RNA sequencing, researchers will explore how these cellular states change before and after treatment, potentially leading to new therapeutic strategies for patients with glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma by targeting its unique cellular environments.
How similar studies have gone: Previous research has shown promise in understanding tumor microenvironments, suggesting that this approach could yield significant insights into glioblastoma treatment.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Canoll, Peter — Mayo Clinic Arizona
- Study coordinator: Canoll, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.