Targeting the different functional states of glioblastoma cancer cells
Evolution and targeting of the functional states of glioblastoma
This study is looking at a type of brain cancer called glioblastoma and aims to create a new way to classify it based on how the cancer cells behave, which could help doctors find better treatments tailored to different groups of patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10876353 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma multiforme (GBM), a highly aggressive brain cancer. It aims to develop a new classification system based on the functional activities of cancer cells rather than traditional biomarkers. By analyzing single-cell transcriptomic data, the researchers have identified four distinct subtypes of GBM, each with unique vulnerabilities. This approach seeks to improve patient outcomes by targeting specific cancer-driving mechanisms in well-defined patient groups.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma multiforme who are seeking targeted treatment options.
Not a fit: Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with glioblastoma.
How similar studies have performed: Other research has shown promise in using functional classifications to improve treatment outcomes in various cancers, suggesting this approach may be effective for glioblastoma as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Lasorella, Anna — University of Miami School of Medicine
- Study coordinator: Lasorella, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.