Targeting T-cell signaling to treat adult T-cell leukemia lymphoma
Inhibition of T-cell Receptor Signaling for Treatment of Adult T-cell Leukemia Lymphoma
This study is looking at how certain changes in T-cell signaling might affect adult T-cell leukemia-lymphoma (ATLL) and is testing a combination of lenalidomide and chemotherapy to see if it can help improve treatment for patients with this cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10880320 on NIH RePORTER |
What this research studies
This research investigates the role of T-cell receptor signaling in adult T-cell leukemia-lymphoma (ATLL), a severe cancer linked to the HTLV-1 virus. The study aims to understand how mutations in this signaling pathway contribute to the disease and explores the potential of lenalidomide, a medication that may help suppress cancer growth when combined with chemotherapy. Patients will be assessed for their T-cell receptor mutations and how these affect treatment outcomes. The research includes a Phase 1 clinical trial to evaluate the effectiveness of this combination therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with HTLV-1-associated adult T-cell leukemia-lymphoma.
Not a fit: Patients with other types of leukemia or those not infected with HTLV-1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with adult T-cell leukemia-lymphoma.
How similar studies have performed: Previous research has shown promising results in targeting T-cell signaling pathways in other cancers, suggesting potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ratner, Lee — Washington University
- Study coordinator: Ratner, Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.