Targeting specific vulnerabilities in colorectal cancer with BRAF mutations
Kinome-guided Targeting of Cooperative Dependencies in BRAF Mutated Colorectal Cancer
This study is looking at a specific type of metastatic colorectal cancer with a BRAF mutation to find better ways to treat it, using a mix of current treatments and new options, so that living with this cancer can become more manageable for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11097186 on NIH RePORTER |
What this research studies
This research focuses on metastatic colorectal cancer (mCRC) that has a BRAF mutation, which is linked to poor treatment outcomes. The team aims to identify and target cooperative dependencies within the cancer cells to improve treatment responses. By utilizing patient-derived models, they will explore the effectiveness of combining existing therapies with new approaches, such as COX2 inhibitors, to enhance tumor suppression and manage the disease more effectively. The goal is to transform BRAFV600E mCRC into a manageable chronic condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic colorectal cancer harboring BRAF mutations.
Not a fit: Patients without BRAF mutations or those with early-stage colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and longer-lasting responses for patients with BRAF-mutated colorectal cancer.
How similar studies have performed: Previous research has shown promise in targeting cooperative dependencies in cancer, indicating potential for success with this approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Coppe, Jean-Philippe Francois Marie — University of California, San Francisco
- Study coordinator: Coppe, Jean-Philippe Francois Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.