Targeting specific types of brain cells to understand their functions
Intersectional transgenic targeting of discrete neuronal and glial subtypes
This study is working on new ways to better understand how different brain cells, like neurons and glial cells, function by using special tools to target and study them more precisely, which could help us learn more about how the brain works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10259997 on NIH RePORTER |
What this research studies
This research focuses on developing advanced tools to specifically target and study different types of neurons and glial cells in the brain. By using innovative intersectional systems, the researchers aim to enhance the precision of gene expression in these cells, which is crucial for understanding their roles in brain function. The approach involves creating specialized vectors that allow for targeted manipulation of gene expression based on the overlap of specific activating factors. This methodology could lead to significant insights into cellular processes and interactions within the nervous system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may benefit from a deeper understanding of brain cell functions.
Not a fit: Patients with conditions unrelated to neuronal or glial cell dysfunction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and the development of targeted therapies for neurological disorders.
How similar studies have performed: Previous research has shown success with similar intersectional targeting approaches in model organisms, indicating potential for effective application in vertebrate systems.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Mumm, Jeffrey — Johns Hopkins University
- Study coordinator: Mumm, Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.