Targeting specific spinal cord neurons to improve chronic pain treatment
Identifying and targeting neural subpopulations of the spinal cord that mediate chronic pain via cell-type-specific cis-regulatory elements
This study is looking at how specific nerve cells in the spinal cord affect chronic pain, with the goal of finding better treatments for people who suffer from it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10903106 on NIH RePORTER |
What this research studies
This research investigates how certain types of neurons in the spinal cord contribute to chronic pain, aiming to develop more effective treatments. By analyzing genetic markers and regulatory elements associated with these neurons in both mice and macaques, the study seeks to identify specific targets for new pain medications. The approach involves understanding the genetic variations that influence pain and how to selectively target the affected neurons. This could lead to more precise and effective pain management strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions who may benefit from more targeted therapeutic options.
Not a fit: Patients with acute pain or those whose pain is not related to spinal cord neuron activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for chronic pain, reducing reliance on current pain medications that often have undesirable side effects.
How similar studies have performed: Other research has shown promise in targeting specific neural populations for pain management, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Leone, Michael — Carnegie-Mellon University
- Study coordinator: Leone, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.