Targeting specific-sized hyaluronan to treat alcoholic liver disease
Specific-sized hyaluronan: a dual targeted therapy for ALD
This study is looking at how certain small pieces of hyaluronan might help people with alcoholic liver disease by reducing inflammation and damage to the liver, and it aims to find new ways to improve liver health for those affected by alcohol use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10457954 on NIH RePORTER |
What this research studies
This research investigates the use of specific-sized hyaluronan fragments to treat alcoholic liver disease (ALD), which affects many individuals with alcohol use disorders. The approach focuses on understanding how these hyaluronan fragments interact with liver cells and immune responses to reduce inflammation and liver damage caused by alcohol consumption. By studying the effects of these fragments in both human and animal models, the research aims to uncover new therapeutic strategies that could improve liver health in patients suffering from ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcoholic liver disease who have a history of alcohol consumption.
Not a fit: Patients who do not consume alcohol or have liver disease due to non-alcoholic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce liver damage and improve outcomes for patients with alcoholic liver disease.
How similar studies have performed: Previous research has shown promise in using targeted therapies for liver diseases, suggesting that this approach may yield beneficial results.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Nagy, Laura E. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Nagy, Laura E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.