Targeting specific signaling pathways in a type of leukemia
Targeting Kinase Inhibitor Induced Signaling Plasticity in Patients with Ph-Like ALL
This study is looking for better ways to treat people with a tough type of leukemia called Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) by testing new treatments that target specific proteins involved in the cancer's growth, hoping to help patients feel better with fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project ID | NIH-11030456 on NIH RePORTER |
What this research studies
This research investigates how to improve treatment for patients with Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL), a high-risk subtype of leukemia. The study focuses on the effects of inhibiting certain kinases that are involved in the cancer's growth and survival. By using a combination of targeted therapies, the researchers aim to identify effective treatment strategies that minimize toxicity while maximizing cancer cell death. Patients may be involved in trials that test these new treatment approaches to see if they can improve outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Philadelphia chromosome-like acute lymphoblastic leukemia, particularly those who have not responded well to standard treatments.
Not a fit: Patients with other types of leukemia or those who do not have Philadelphia chromosome-like ALL may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for patients with Ph-like ALL.
How similar studies have performed: Previous research has shown promise in targeting similar signaling pathways in other types of leukemia, suggesting that this approach may be effective.
Where this research is happening
Loma Linda, UNITED STATES
- Loma Linda University — Loma Linda, United States (Active)
Researchers
- Principal investigator: Hurtz, Christian — Loma Linda University
- Study coordinator: Hurtz, Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.