Targeting specific proteins to treat aggressive nerve tumors
Therapeutic Targeting of Receptor Tyrosine Kinase Hierarchies in Schwann Cell Neoplasms
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-10883651
This study is looking at a type of aggressive tumor called malignant peripheral nerve sheath tumors (MPNSTs) that can affect people with neurofibromatosis type 1 (NF1), and it aims to find better treatments by targeting certain proteins that help these tumors grow.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10883651 on ClinicalTrials.gov |
What this research studies
This research focuses on malignant peripheral nerve sheath tumors (MPNSTs), which are aggressive tumors that arise from Schwann cells, particularly in patients with neurofibromatosis type 1 (NF1). The study investigates the role of receptor tyrosine kinases (RTKs) in the growth of these tumors and aims to find effective treatments by targeting these proteins. Using advanced screening methods, the researchers have identified specific inhibitors that may reduce tumor growth and Ras activation, which is crucial for the survival of MPNST cells. Patients may benefit from new therapeutic options that are more effective than current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with malignant peripheral nerve sheath tumors, especially those with neurofibromatosis type 1.
Not a fit: Patients with other types of tumors or those without Schwann cell lineage tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for patients with malignant peripheral nerve sheath tumors.
How similar studies have performed: Previous research has shown promise in targeting receptor tyrosine kinases in other cancer types, suggesting potential for success in this novel approach for MPNSTs.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARROLL, STEVEN L. — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: CARROLL, STEVEN L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.