Targeting specific proteins to improve cancer treatment
Official title: Cyclin Dependent Kinases as Epigenetic Therapy Targets
Funded at Coriell Institute for Medical Research · NIH-10886781 · Data updated 2026-11-12
This study is looking for new ways to help treat myeloid leukemias by finding drugs that can change how cancer cells behave, making them more responsive to current treatments and possibly helping the immune system fight the cancer better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | August 16, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $514,307 |
| NIH project number | 5P50CA254897-04 |
| Project ID | NIH-10886781 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with myeloid leukemias or other cancers that may benefit from epigenetic therapies.
✕Less likely to help
Patients with cancers that do not involve the targeted pathways or those who are not responsive to epigenetic therapies may not benefit from this research.
What this research studies
This research focuses on developing new epigenetic therapies that can reprogram gene expression in cancer cells, particularly in myeloid leukemias. By screening for drugs that inhibit a protein called CDK9, the researchers aim to activate silenced genes and suppress oncogenes, potentially enhancing the effectiveness of existing cancer treatments. The approach involves using live cell assays to identify compounds that can achieve significant changes in gene expression, which may also help to boost the immune response against tumors. This innovative strategy could lead to more effective cancer therapies by combining gene regulation with immunotherapy.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve outcomes for patients with certain types of cancer.
How similar studies have gone: Other research has shown promising results with similar approaches targeting cyclin-dependent kinases in cancer therapy, indicating potential for success.
Where this research is happening
-
Coriell Institute for Medical Research
Camden, United States Active
Researchers
- Principal investigator: Issa, Jean-Pierre J. — Coriell Institute for Medical Research
- Study coordinator: Issa, Jean-Pierre J.
Related research
Other NIH-funded projects on the same topics.
-
Mysterious DNA marks in sperm and eggs: how sex shapes germline methylation
This grant looks at how DNA methylation patterns in sperm and eggs become different between the sexes and why that matters for fertility and healthy offspring.
-
NIGMS Human Genetic Cell Repository Support
A national biobank helps scientists by keeping high-quality human cell lines and DNA from people with genetic differences and healthy individuals for research and teaching.
-
Centralized bank of human cell lines and DNA for biomedical research
A national repository funded by NIH provides high-quality human cell lines and DNA from people with inherited disorders and diverse backgrounds to researchers.
-
Human Genetic Cell Repository for Biomedical Research
A national resource center will keep and expand a library of well-documented human cell lines and DNA from people with inherited disorders and diverse backgrounds to help researchers study genetic diseases.
-
NIGMS Human Genetic Cell Repository for Biomedical Research
This NIH grant supports Coriell to maintain and expand a centralized collection of human cell lines and DNA from people with inherited disorders and diverse backgrounds to speed biomedical discoveries.
-
NHGRI Sample Repository for Human Genetic Research
A national resource is renewed to provide a large, publicly accessible collection of human biospecimens and genomic data to support trustworthy genetic research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.